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Hydrogen potassium ATPase : ウィキペディア英語版 | Hydrogen potassium ATPase
Gastric hydrogen potassium ATPase, also known as H+/K+ ATPase, is an enzyme whose purpose is to acidify the stomach. == Biological function and location == The gastric hydrogen potassium ATPase or H+/K+ ATPase is the proton pump of the stomach. It exchanges potassium from the intestinal lumen with cytoplasmic hydronium and is the enzyme primarily responsible for the acidification of the stomach contents and the activation of the digestive enzyme pepsin (see gastric acid). The H+/K+ ATPase is found in parietal cells, which are highly specialized epithelial cells located in the inner cell lining of the stomach called the gastric mucosa. Parietal cells possess an extensive secretory membrane system and the H+/K+ ATPase is the major protein constituent of these membranes. A small amount of H+/K+ ATPase is also found in the renal medulla.〔
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